Protein Phosphatases Regulate DNA-dependent Protein Kinase Activity
نویسندگان
چکیده
منابع مشابه
Protein phosphatases regulate DNA-dependent protein kinase activity.
DNA-dependent protein kinase (DNA-PK) is a complex of DNA-PK catalytic subunit (DNA-PKcs) and the DNA end-binding Ku70/Ku80 heterodimer. DNA-PK is required for DNA double strand break repair by the process of nonhomologous end joining. Nonhomologous end joining is a major mechanism for the repair of DNA double strand breaks in mammalian cells. As such, DNA-PK plays essential roles in the cellul...
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The DNA-dependent protein kinase (DNA–PK) is a nuclear serine/threonine protein kinase that is activated upon association with DNA. Biochemical and genetic data have revealed DNA–PK to be composed of a large catalytic subunit, termed DNA–PKcs, and a regulatory factor termed Ku. In recent years, mammalian DNA–PK has been shown to be a crucial component of both the DNA double-strand break (DSB) r...
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The DNA-dependent protein kinase (DNA–PK) is a nuclear serine/threonine protein kinase that is activated upon association with DNA. Biochemical and genetic data have revealed DNA–PK to be composed of a large catalytic subunit, termed DNA–PKcs, and a regulatory factor termed Ku. In recent years, mammalian DNA–PK has been shown to be a crucial component of both the DNA double-strand break (DSB) r...
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Protein tyrosine phosphatases (PTPs) form a large family of enzymes that serve as key regulatory components in signal transduction pathways. Defective or inappropriate regulation of PTP activity leads to aberrant tyrosine phosphorylation, which contributes to the development of many human diseases. In addition to controlling the phosphorylation states of protein kinase substrates, PTPs can also...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m011703200